The trip from Amarillo to Oklahoma City is a 4-hour drive covering 420 km. You will travel east on I-40, crossing the Texas Panhandle into Oklahoma. This is a very popular route for travelers heading to the Midwest. The terrain is flat and open. There is no practical train or flight service between these two cities.
Total Distance: 420 km driving, 400 km air distance.
Watch for speed traps in small towns along the way.
Spring or autumn for pleasant weather.