Is there a train to St. Louis?

Amtrak's Lincoln Service and Texas Eagle lines serve St. Louis, but there is no rail from Amarillo.

How long is the drive?

It is approximately 13 hours of driving time.

Are there direct flights?

No, all flights from Amarillo to St. Louis require a connection.

What is the best way to travel?

Flying is the most convenient method.

Yes, tourist areas are generally safe, but stay aware of your surroundings.

Amarillo

St. Louis

Flight Driving

Amarillo to St. Louis

Updated: 28 May 2026

The journey from Amarillo to St. Louis is a straightforward trip across the Midwest, primarily following I-40 and I-44. Flying is the most efficient option, with connections in hubs like Dallas or Kansas City. If you choose to drive, you will pass through Oklahoma and Missouri. This is a manageable drive that can be completed in about 12-13 hours. St. Louis is a historic city with much to offer, so plan your itinerary in advance.

Total Distance: Driving distance 1,200 km, straight-line air distance 1,000 km.

Fastest Way

Flight via Southwest or American takes about 5 hours.

Cheapest Way

Driving is the most economical for groups.

Compare Amarillo to St. Louis Routes

	Flight Connecting	Driving Direct
Duration	5 hours	13 hours
Avg Price	$250 - $450	$150 - $250 in fuel
Operator	Southwest Airlines	Personal Vehicle
Route	AMA to STL via DAL or MCI.	I-40 E to I-44 E.
Tip	St. Louis Lambert International Airport (STL) is well-connected to the city via the MetroLink.	I-44 is a direct route from Amarillo to St. Louis; watch for construction in Oklahoma.

Travel Tips

St. Louis Traffic
St. Louis traffic is generally manageable; use navigation apps to avoid delays.
Public Transit
The MetroLink light rail is a convenient way to get around the city.
Weather
St. Louis has four distinct seasons; pack accordingly.
Food
Try a local St. Louis-style pizza, famous for its thin, cracker-like crust.
Airport Access
The MetroLink train runs directly from STL to downtown.