How long is the flight?

It takes about 8 hours with a connection.

Is it better to drive or fly?

Flying is much faster; driving is only recommended if you want a road trip.

What is the best route to drive?

I-81 S to I-95 S to US-1 S is a standard route.

Are there direct flights?

No, you will typically need a connection.

What is the best time to visit?

Late autumn to early spring offers the most pleasant weather.

Amherst

Key West

Flight Driving

Amherst to Key West

Updated: 28 May 2026

The journey from Amherst to Key West is approximately 1,650 miles. Flying is the most efficient method, taking about 8 hours with a connection. Driving is a long-distance trip, requiring about 25 hours of road time, usually split over 3 days. You will travel down the East Coast and then take the scenic Overseas Highway through the Florida Keys. This route is popular for those seeking a tropical getaway.

Total Distance: 2,655 km driving distance, 2,200 km air distance.

Fastest Way

Flying is significantly faster, saving you nearly 17 hours of travel time.

Cheapest Way

Driving is generally more cost-effective for families, while flying is better for solo travelers.

Compare Amherst to Key West Routes

	Flight Connecting	Driving Direct
Duration	8 hours	25 hours
Avg Price	$350-$650	$350-$500 in fuel
Operator	American Airlines	Personal Vehicle
Route	BUF to EYW (Key West) via a hub like MIA.	I-81 S to I-95 S to US-1 S.
Tip	Book early to secure lower fares, especially during peak travel seasons.	Plan for at least two overnight stops to maintain safety.

Travel Tips

Flight Connections
Look for flights connecting through major hubs to minimize total travel time.
Driving Breaks
Stop in cities like Richmond or Miami to break up the long drive.
Overseas Highway
The drive through the Keys is beautiful; take your time and enjoy the views.
Sun Protection
The Florida sun is strong; pack sunscreen and hats even in the winter.
Parking
Parking in Key West can be difficult; use public parking garages or hotel parking.

Safety Tips

Driving Safety
Avoid driving through major cities during peak rush hours to reduce stress.
Weather
Be aware of potential severe weather in the South, especially during hurricane season.
Vehicle Prep
Check your cooling system before driving into the Florida heat.
Emergency Kit
Keep a well-stocked emergency kit in your car for the long-distance drive.