There is no direct passenger rail service between Beaufort and Chicago.

How long is the drive?

The drive takes approximately 14 hours depending on traffic.

Yes, there are many toll roads in the Midwest; prepare accordingly.

Early morning is best to avoid the worst of the traffic.

Is it a scenic drive?

It is mostly an interstate drive through forests and urban areas.

Beaufort

Chicago

Driving

Beaufort to Chicago

Updated: 29 May 2026

The drive from Beaufort to Chicago covers approximately 1,400 kilometers and typically takes 14 hours via I-26 and I-65. You will travel through the coastal plains of South Carolina and into the Midwest. This is a very long drive, so plan for multiple stops. Expect heavy traffic near major cities like Indianapolis and Chicago.

Total Distance: 1,400 km driving distance; 1,200 km straight-line air distance.

Fastest Way

Driving is the fastest method as there are no direct public transport options.

Cheapest Way

Driving your own vehicle is the most economical way to reach Chicago.

Compare Beaufort to Chicago Routes

Driving

Direct

Duration

14 hours

Avg Price

$180 - $240 in fuel

Operator

Personal Vehicle

Route

I-26 W to I-65 N.

I-65 in the Midwest is extremely busy; check for accidents before entering the area.

Travel Tips

I-65 Traffic
I-65 in the Midwest is notorious for traffic; use navigation apps to find alternate routes.
Tolls
Many roads in the Midwest are tolled; ensure you have an I-PASS account.
Departure Time
Leave very early in the morning to arrive in Chicago before the afternoon rush hour.
Hydration
Keep plenty of water in the car, especially during the hot summer months.
Rest Stops
Use the official state rest areas along I-65 for safe and convenient breaks.

Safety Tips

Aggressive Drivers
Chicago highways see many drivers; stay alert and maintain a safe following distance.
Weather
Midwest weather can be unpredictable; check for snow or heavy rain before leaving.
Vehicle Maintenance
Check your tire pressure and fluid levels before embarking on this long drive.
Emergency
Know your location on the highway by noting the nearest exit number in case of an emergency.