Is it better to fly or drive?

Flying is much faster, but driving is more flexible for those who want to see the Midwest.

How long does the drive take?

It takes about 16 to 18 hours of driving time.

What is the best route?

The most common route is via I-70 West.

There are very few tolls on this route, making it a cost-effective drive.

Is St. Louis safe for tourists?

Yes, St. Louis is very tourist-friendly, but stay aware of your surroundings in busy areas.

Berlin

St. Louis

Driving

Berlin to St. Louis

Updated: 30 May 2026

The drive from Berlin, Maryland to St. Louis, Missouri is a major cross-country journey of approximately 1,000 miles. You will travel west through several states, primarily via I-70. This trip requires at least two days of driving to ensure safety. Driving is the most practical mode for those who want to explore the Midwest. Expect a total driving time of about 16 to 18 hours.

Total Distance: 1,610 km driving distance; 1,350 km straight-line air distance.

Fastest Way

Driving via the interstate highway system is the most direct route to St. Louis.

Cheapest Way

Driving is the most economical way to travel, especially for groups or families.

Compare Berlin to St. Louis Routes

Driving

Direct

Duration

16 hours

Avg Price

$170-$250 in fuel

Operator

Personal Vehicle

Route

US-113 North to I-70 West.

Plan overnight stops in cities like Columbus, OH or Indianapolis, IN.

Travel Tips

Multi-Day Trip
Do not attempt this drive in less than two days; split it into three days to stay safe and refreshed.
Traffic Planning
St. Louis traffic can be heavy; try to arrive outside of peak morning and evening hours.
Hotel Booking
Book your overnight stops in advance, especially during the busy tourist season.
Snack Prep
Pack plenty of water and healthy snacks to keep energy levels up during the long drive.
GPS Usage
Use a reliable GPS to navigate the complex highway interchanges in Missouri.

Safety Tips

Driver Rotation
Rotate drivers every few hours to prevent fatigue on the long highway stretches.
Vehicle Maintenance
Check your tires, oil, and coolant levels before starting this long-distance trip.
Emergency Kit
Carry a well-stocked emergency kit, including a first-aid kit and jumper cables.
Weather Awareness
Be prepared for sudden rainstorms, which are common in Missouri, especially in the summer.