The drive from Billings to Cheyenne is approximately 450 miles. You will travel south on I-90 and transition to I-25 through Casper. The journey takes about 6 to 7 hours depending on weather and traffic. You will pass through the high plains of Wyoming. This route is a common path for those traveling between the northern and southern Rockies.
Total Distance: 720 km driving, 650 km air.
Watch for high winds on the Wyoming plains.
Summer and early autumn to avoid winter snow on I-25.