The drive from Birmingham to Lexington is a 650-kilometer journey taking about 6.5 hours. You will head north on I-65 to Nashville, then transition to I-65/I-24/I-75 or similar routes depending on traffic. This drive takes you through the heart of Tennessee and into the beautiful Bluegrass region of Kentucky. It is a scenic drive, especially in the spring.
Total Distance: 650 km driving, 550 km air distance.
Nashville traffic can be very heavy; plan your timing carefully.
Spring for the horse country scenery or autumn for the fall colors.