The drive from Blowing Rock to Greenville covers approximately 150 km. The most direct route takes about 2 hours via US-221 S and I-26 E. You will descend from the Blue Ridge Mountains into the Piedmont region and then into South Carolina. This is a straightforward drive that is best done in a single day. You will transition from the high-altitude mountain town of Blowing Rock to the city of Greenville.
Total Distance: 150 km driving distance; 130 km straight-line air distance.
The drive is scenic as you descend from the mountains.
Spring or Autumn for pleasant weather and beautiful scenery.