The journey from Bonita Springs to Tallahassee is a 600-kilometer drive, typically taking six hours. You will travel north on Interstate 75 before heading west on Interstate 10. This route takes you through the heart of Florida's interior and into the Panhandle. It is a long but straightforward drive. Expect to pass through several major Florida cities along the way.
Total Distance: 600 km driving distance, 550 km air distance.
Plan for a stop in Lake City to switch from I-75 to I-10.
Spring for the blooming azaleas in Tallahassee.