Brookline
Brookline
Key West
Key West
Flight Driving

Brookline to Key West

Updated: 28 May 2026

The journey from Brookline to Key West covers about 2,500 kilometers. Flying from Boston Logan to Key West International Airport (EYW) is the most practical choice. Driving is a very long, multi-day trip down the entire East Coast and through the Florida Keys. Key West is famous for its tropical climate, nightlife, and water activities. Plan your travel to avoid peak hurricane season.

Total Distance: Driving distance 2,500 km, air distance 2,200 km.
Fastest Way
Flight from BOS to EYW takes 6 hours.
Cheapest Way
Driving is the most economical for groups.
Compare Brookline to Key West Routes
Flight
Connecting
Driving
Direct
Duration 6 hours 26 hours
Avg Price $400 - $900 $350 in fuel
Operator American Airlines Personal Vehicle
Route BOS to EYW via CLT or MIA. I-95 S to US-1 S.
Tip Connecting flights are standard for this route. The drive through the Florida Keys is scenic.
Travel Tips
  • Driving
    Be prepared for long, traffic-heavy stretches.
  • Weather
    Summers are hot; avoid hurricane season.
  • Transport
    A car is not needed in Key West.
  • Dining
    Try the local key lime pie.
  • Airport
    EYW is about 10 minutes from downtown.
Safety Tips
  • Driving
    Stay alert on long highway stretches.
  • Urban Safety
    Standard city safety applies.
  • Weather
    Watch for severe thunderstorms.
  • Emergency
    Keep extra supplies in your car.
People Also Ask
  • Is Key West safe?
    Yes, it is generally safe in tourist areas.
  • What is the best time to visit?
    Winter.
  • Is it expensive?
    Key West can be pricey.
  • Are there direct flights?
    No, expect a connection.
  • What is the drive like?
    It is a very long, multi-day drive.
Quick Info
  • From Brookline, Massachusetts, United States
  • To Key West, Florida, United States
  • Modes
Best Time to Travel

December to April for pleasant weather.

Things to Do in Key West
1
Duval Street
The heart of Key West nightlife.
2
Ernest Hemingway Home
A historic home and museum.
3
Mallory Square
Famous for its sunset celebrations.
4
Dry Tortugas National Park
A remote park accessible by ferry or seaplane.
Tags
Brookline to Key West travel flights to Key West driving to Key West Key West travel guide best route to Key West Massachusetts to Florida travel Logan Airport to EYW Key West transport