How long is the drive?

The drive takes approximately 10 hours.

You can fly from Asheville (AVL) to St. Louis (STL) with connections.

What is the best route?

I-40 to I-65 to I-64 is the standard and most efficient route.

Burnsville

Saint Louis

Driving

Burnsville to Saint Louis

Updated: 29 May 2026

The trip from Burnsville to St. Louis is a significant 950-kilometer trek across the heart of the United States. You will head west on I-40 before connecting to I-64, passing through Tennessee and Southern Illinois. This journey typically takes 10 hours of driving time. It is a cross-country route that transitions from the Appalachian Mountains to the flat plains of the Midwest. Plan for multiple stops to manage the long duration of this trip.

Total Distance: 950 km driving distance; 820 km straight-line air distance.

Fastest Way

Driving via the interstate system is the fastest, taking 10 hours.

Cheapest Way

Driving is the most cost-effective way to cover this distance.

Compare Burnsville to Saint Louis Routes

Driving

Direct

Duration

10 hours

Avg Price

$140-$180 in fuel

Operator

Personal Vehicle

Route

I-40 W to I-65 N to I-64 W.

Consider an overnight stop in Nashville if you prefer not to drive 10 hours straight.

Travel Tips

Plan Stops
Nashville is a great midway point for food and rest.
Traffic
Expect heavy traffic when entering St. Louis during the evening commute.
Navigation
Use a reliable GPS to navigate the complex highway interchanges in St. Louis.
Hydration
Keep plenty of water in the car for the long drive.
Music
Prepare a long playlist or audiobooks to keep you entertained.

Safety Tips

Driver Fatigue
Do not push yourself to drive the full 10 hours if you feel tired.
Vehicle Maintenance
Check your oil and coolant levels before departing.
Weather Awareness
Midwest storms can be severe; check forecasts along the route.
Emergency Supplies
Keep a flashlight and first-aid kit in your vehicle.