The journey from Calexico to Las Vegas covers approximately 450 kilometers through the Mojave Desert. You will primarily utilize Highway 111 north to I-10, eventually merging onto I-15 North at Ontario. This route takes roughly 5 hours depending on traffic near the Cajon Pass. The landscape transitions from the agricultural Imperial Valley to the rugged desert terrain of Southern Nevada. Expect significant temperature fluctuations between the valley floor and the mountain passes.
Total Distance: 450 km driving distance; 380 km straight-line air distance.
Fill your gas tank in El Centro before entering the desert stretches.
October to April to avoid extreme desert heat in the Mojave.