Key West is approximately 1,600 miles from Cambridge. The most practical way to travel is by flying from Boston Logan International Airport (BOS) to Key West International Airport (EYW). The flight takes about 4 hours. Driving would take over 28 hours, which is not recommended. Once in Key West, you can use the local bus or rent a bicycle.
Total Distance: 2,700 km driving, 2,200 km air distance.
Book connecting flights through Miami or Charlotte.
March to May for pleasant weather and to avoid hurricane season.