The drive from Cheektowaga to Baltimore is approximately 350 miles. You will typically head south on I-81 before connecting to I-70 East. This route takes about 6 hours. It is a straightforward drive through Pennsylvania and Maryland. Plan for traffic near the Baltimore beltway.
Total Distance: 560 km driving distance; 450 km straight-line air distance.
Avoid Baltimore rush hour to save time.
Spring or Fall for the best weather in Baltimore.