The drive from Cheektowaga to Columbus is approximately 300 miles. You will typically head west on I-90 before transitioning to I-71 South near Cleveland. This route takes you through the heart of Ohio. Expect a travel time of about 5 hours under normal conditions. The drive is straightforward and well-marked.
Total Distance: 480 km driving distance; 400 km straight-line air distance.
Stop in Cleveland for lunch to break up the drive.
Spring and Autumn offer the most pleasant driving conditions.