The distance from Cheektowaga to Los Angeles is over 2,500 miles, making flying the only practical mode of transport. You can fly from Buffalo Niagara International Airport (BUF) to Los Angeles International Airport (LAX), which takes about 5 hours and 30 minutes in the air. There are no direct flights, so you will likely connect through a major hub like Chicago, Denver, or Dallas.
Total Distance: 4000 km driving, 3600 km air distance.
Book in advance for the best seat prices.
Spring or Fall for pleasant weather and fewer crowds.