The drive from Columbus to Milwaukee is approximately 330 miles. You will typically take I-65 North to I-94 West. This is a major commute that typically takes 5 hours and 30 minutes. Milwaukee is a historic city on Lake Michigan known for its beer and culture.
Total Distance: 530 km driving, 470 km straight-line.
Traffic in Milwaukee is very heavy; consider parking outside the city.
Any time, but avoid morning and evening rush hours in Milwaukee.