The drive from Danville to Charleston is approximately 350 miles. You will travel south through North Carolina and South Carolina. The most direct route involves taking US-29 S and I-77 S to I-26 E. This journey takes you through the heart of the South. Expect a drive time of about 6 to 7 hours depending on traffic and road conditions.
Total Distance: Driving distance 550 km, straight-line air distance 450 km.
Be prepared for heavy traffic in the Charlotte area.
March to May or September to November for pleasant weather.