The drive from Danville to Nashville is a manageable 450-mile journey. You will primarily travel west on US-58 and I-81, eventually connecting to I-40 W. This route takes you through the scenic Appalachian Mountains and across the heart of Tennessee. It is a popular route for those looking to experience the musical heritage of the South. Expect a drive time of approximately 7 to 8 hours depending on traffic.
Total Distance: Driving distance 720 km, straight-line air distance 600 km.
Stop in Knoxville for a break; it is roughly the halfway point.
April to June or September to October for mild weather.