The drive from Deerfield Beach to Key West is one of the most scenic in the United States. You will travel south to Miami and then take US-1, the Overseas Highway, through the Florida Keys. The journey takes about 4 to 5 hours depending on traffic. You will cross dozens of bridges, including the famous Seven Mile Bridge. This is a bucket-list road trip for many travelers.
Total Distance: 300 km driving, 260 km air distance.
The Overseas Highway is a single-lane road; traffic can be slow.
March to May for the best weather and fewer crowds.