Del Rio
Del Rio
Key West
Key West
Flight Driving

Del Rio to Key West

Updated: 30 May 2026

The journey from Del Rio to Key West covers approximately 2,300 km. Driving via I-10 E and US-1 S is a major trip, taking about 24 hours. Alternatively, flying from San Antonio International Airport to Key West International Airport is a convenient option. Key West is known for its laid-back atmosphere, historic sites, and beautiful sunsets. This route takes you across the Gulf Coast and down the Florida Keys.

Total Distance: 2,300 km driving, 2,100 km air distance.
Fastest Way
Flying from San Antonio International Airport is the fastest, taking about 8 hours.
Cheapest Way
Driving is the most economical for families traveling to Key West.
Compare Del Rio to Key West Routes
Flight
Connecting
Driving
Direct
Duration 8 hours 24 hours
Avg Price $350 - $600 $300 - $450 in fuel
Operator American Airlines Personal Vehicle
Route SAT to EYW via Miami or Dallas. I-10 E to US-1 S through Louisiana, Mississippi, Alabama, and Florida.
Tip Key West International is very small and convenient. The drive down the Overseas Highway is one of the most scenic in the country.
Travel Tips
  • Airport Arrival
    Key West International is very convenient for accessing the city.
  • Traffic
    Traffic on the Overseas Highway can be heavy, especially on weekends.
  • Weather
    Be prepared for humid summers and mild winters in Florida.
  • Dining
    Try the local Key Lime pie for an authentic experience.
  • Booking
    Book flights in advance to get the best rates.
Safety Tips
  • Weather Monitoring
    Stay updated on severe weather alerts, especially during hurricane season.
  • Vehicle Prep
    Check your tires and battery before a long drive.
  • Emergency Kit
    Keep a basic emergency kit in your vehicle.
  • Sun Safety
    The Florida sun is intense; always carry sunscreen and hats.
People Also Ask
  • Is Key West a good city for tourists?
    Yes, it offers a great mix of history, culture, and family-friendly attractions.
  • How long is the drive?
    The drive takes about 24 hours of pure transit time.
  • Are there direct flights?
    Direct flights are rare; most require a connection.
  • What is the best way to get around?
    A car is recommended for exploring the city and surrounding areas.
  • Is it cheaper to fly or drive?
    Driving is cheaper for groups, while flying is faster for individuals.
Quick Info
  • From Del Rio, Texas, United States
  • To Key West, Florida, United States
  • Modes
Best Time to Travel

Winter and early spring are best to avoid the intense Florida summer heat.

Things to Do in Key West
1
Ernest Hemingway Home
Tour the historic home of the famous author. It is a must-see.
2
Mallory Square
Watch the famous sunset celebration with street performers and local vendors. It is a local tradition.
3
Southernmost Point
Take a photo at the iconic buoy marking the southernmost point in the continental US. It is a popular tourist spot.
4
Dry Tortugas National Park
Take a ferry or seaplane to this remote park featuring a historic fort and beautiful beaches. It is a unique experience.
Tags
Del Rio to Key West driving to Florida Keys from Texas flights to Key West Texas to Florida Keys travel I-10 route San Antonio airport Key West travel guide vacation planning