Is there a train to St. Louis?

Amtrak does not offer a direct route from Denver to St. Louis.

How long is the drive?

The drive is approximately 13 hours without stops.

Are there direct flights?

Yes, Southwest and United offer direct flights from DEN to STL.

What is the best highway?

Interstate 70 is the primary and most efficient route.

Like any major city, stick to well-lit, populated areas and use common sense.

Denver

St. Louis

Flight Driving

Denver to St. Louis

Updated: 28 May 2026

The journey from Denver to St. Louis spans approximately 850 miles across the Great Plains. Most travelers utilize Interstate 70 East, which provides a direct corridor through Kansas. Direct flights are available from Denver International Airport to St. Louis Lambert International Airport. The drive typically takes 13 hours of pure transit time. You will cross the Missouri River as you approach the Gateway City. This route is a classic American transit path connecting the Rockies to the Mississippi River.

Total Distance: 1,368 km driving distance; 1,230 km straight-line air distance.

Fastest Way

Flying from Denver International Airport takes just over two hours.

Cheapest Way

Driving is the cheapest for groups of two or more people.

Compare Denver to St. Louis Routes

	Flight Direct	Driving Direct
Duration	2 hours 15 mins	13 hours
Avg Price	$180-$400	$150-$250 in fuel
Operator	Southwest Airlines	Personal Vehicle
Route	DEN to STL.	I-70 East through Kansas City and Columbia.
Tip	Book at least three weeks in advance for lower fares.	Check for construction in Kansas City before departing.

Travel Tips

Kansas Tolls
I-70 in Kansas is largely toll-free, making it a cost-effective drive.
Time Zone
You will cross from Mountain Time to Central Time during your journey.
Airport Transit
Use the MetroLink light rail to get from STL airport to downtown St. Louis.
Pack Layers
Denver's high altitude and St. Louis's humidity require versatile clothing.
Rest Stops
Stop in Hays, Kansas, for a mid-way break with plenty of dining options.

Safety Tips

Winter Driving
I-70 can experience severe blizzards; check the Kansas Department of Transportation website.
Wildlife
Be alert for deer crossing the highway, especially during dawn and dusk.
Vehicle Check
Ensure your tires are inflated properly for the long, high-speed stretch across Kansas.
Emergency Kit
Carry water, blankets, and a portable charger in your car for remote stretches.