The drive from Desert Hot Springs to San Diego is approximately 130 miles. You will take I-10 West to I-15 South. The journey typically takes 2.5 to 3.5 hours depending on traffic. This route takes you from the desert through the mountains to the coast.
Total Distance: Driving distance 210 km; Air distance 160 km.
The I-15 can be very congested near Temecula.
Weekdays to avoid weekend traffic on I-15.