Is there a train to St. Louis?

Amtrak does not offer a direct route from Detroit to St. Louis.

How long is the drive?

The drive is approximately 8.5 hours under normal conditions.

Are there direct flights?

Yes, Southwest Airlines operates direct flights between DTW and STL.

What is the best highway?

I-75 South to I-70 West is the most efficient path.

Yes, the route is well-maintained and heavily traveled.

Detroit

St. Louis

Flight Driving

Detroit to St. Louis

Updated: 28 May 2026

The journey from Detroit to St. Louis covers approximately 850 kilometers. Most travelers prefer driving via I-75 South to I-70 West through Indianapolis. Direct flights are available from Detroit Metropolitan Airport to St. Louis Lambert International. The drive typically takes 8 to 9 hours depending on traffic near Indianapolis. This route crosses through the heart of the Midwest, offering diverse landscapes.

Total Distance: 850 km driving, 720 km air distance.

Fastest Way

Flight takes 1 hour 45 minutes plus airport transit time.

Cheapest Way

Driving is the cheapest for groups of two or more.

Compare Detroit to St. Louis Routes

	Flight Direct	Driving Direct
Duration	1 hour 45 mins	8 hours 30 mins
Avg Price	$250-$450	$120-$180 in fuel
Operator	Southwest Airlines	Personal Vehicle
Route	DTW to STL	I-75 S to I-70 W via Indianapolis
Tip	Book at least three weeks in advance for lower fares.	Avoid rush hour traffic in Indianapolis to save 45 minutes.

Travel Tips

Toll Roads
Carry an E-ZPass to handle tolls efficiently on the Ohio Turnpike.
Traffic Alerts
Use real-time navigation apps to bypass congestion in Indianapolis.
Rest Stops
Stop in Richmond, Indiana for a mid-way break.
Parking
Pre-book parking in downtown St. Louis to save on daily rates.
Weather
Check for winter storm warnings if traveling between December and March.

Safety Tips

Vehicle Check
Ensure tire pressure is optimal before starting the long drive.
Night Driving
Avoid driving through rural stretches of I-70 late at night due to deer activity.
Emergency Kit
Keep a basic roadside emergency kit in your trunk.
Stay Alert
Switch drivers every 4 hours to prevent fatigue.