There is no regular, scheduled bus service between these two cities.

What is the best route?

Taking US-281 to I-94 to I-29 is the most efficient path.

No, there are no toll roads on this route.

Yes, it is a standard highway drive, though winter weather requires caution.

Devils Lake

Sioux Falls

Driving

Devils Lake to Sioux Falls

Updated: 29 May 2026

The drive from Devils Lake to Sioux Falls is a 350-mile trip that takes you south through the heart of North Dakota and into South Dakota. You will travel south on US-281 to Jamestown, then east on I-94 to Fargo, and finally south on I-29 to Sioux Falls. The drive typically takes about 6 hours. This route connects the rural lake region to the largest city in South Dakota.

Total Distance: 560 km driving distance; 530 km straight-line air distance.

Fastest Way

Driving via US-281, I-94, and I-29 is the fastest and only direct route.

Cheapest Way

Driving your own vehicle is the most practical and affordable option.

Compare Devils Lake to Sioux Falls Routes

Driving

Direct

Duration

6 hours

Avg Price

$50-$70 in fuel

Operator

Personal Vehicle

Route

US-281 S to I-94 E to I-29 S.

Fargo is a great place to stop for lunch or a quick break.

Travel Tips

Speed Limits
Be careful to slow down when entering the small towns along the route.
Weather
Winter storms can make I-29 treacherous; check the NDDOT and SDDOT websites before departing.
Fueling
There are many fuel stations along the route, especially in larger cities like Fargo.
Traffic
Traffic is generally light, but be aware of construction during the summer months.
Navigation
The route is well-marked, but keep a GPS device or map handy for the transition between highways.

Safety Tips

Winter Driving
Always carry a winter emergency kit, as blowing snow can reduce visibility to zero.
Wildlife
Deer are frequently seen near the highway; stay alert at all times.
Fatigue
Take regular breaks to stay alert on this long drive.
Visibility
Use your headlights during the day if conditions are overcast or snowy.