The drive from Duluth to Jacksonville is about 550 kilometers. You will take I-85 South to I-95 South. The drive takes about 5.5 to 6 hours. This is a very popular route for those heading to the Florida coast.
Total Distance: 550 km driving, 500 km air distance.
I-95 can have heavy traffic near the Georgia-Florida border.
Spring and fall are ideal for visiting the coast.