The journey from Duluth to St. Louis is a 900-kilometer drive. Driving via I-75 North and I-64 West is the most practical method, taking about 9 hours. You will pass through Nashville and Southern Illinois. This route connects the South to the Midwest.
Total Distance: 900 km driving, 750 km air distance.
Be prepared for long stretches of highway driving.
May to June or September to October for mild weather.