The drive from East Syracuse to Buffalo is approximately 150 miles and takes about 2.5 hours. You will travel west through New York state. This route is efficient and offers a variety of scenery. Buffalo is a historic city known for its architecture, food, and proximity to Niagara Falls.
Total Distance: 240 km driving, 200 km air distance.
Expect heavy traffic near Buffalo.
Spring or Autumn for comfortable weather.