Amtrak offers service, but it requires a connection in Chicago.

How long is the drive?

Approximately 8 hours of pure driving time.

No major tolls on this specific interstate route.

Des Moines, Iowa is the perfect midpoint for a break.

Yes, the route is well-traveled and safe for families.

Eden Prairie

St. Louis

Driving

Eden Prairie to St. Louis

Updated: 29 May 2026

The drive from Eden Prairie to St. Louis covers approximately 500 miles. You will primarily travel south on I-35 before connecting to I-70 East. The journey takes roughly 8 hours of driving time depending on traffic in Des Moines. This route traverses the heart of the American Midwest through Iowa and Missouri. It is a straightforward drive suitable for a single-day trip.

Total Distance: Driving distance 800 km; Air distance 680 km.

Fastest Way

Driving via I-35 and I-70 is the fastest, taking 8 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method for groups.

Compare Eden Prairie to St. Louis Routes

Driving

Direct

Duration

8 hours

Avg Price

$80 - $120 (fuel)

Operator

Personal Vehicle

Route

I-35 S to I-80 E to I-70 E.

Stop in Des Moines for a quick lunch break to break up the drive.

Travel Tips

Traffic
Avoid downtown St. Louis during morning and evening rush hours.
Parking
Use parking apps to find affordable garages near the Arch.
Route
Check for construction on I-70 near the Missouri border before departing.
Rest Stops
Iowa has excellent rest areas along I-35 with clean facilities.
Dining
Try St. Louis-style pizza and toasted ravioli at local eateries.

Safety Tips

Weather
Be prepared for sudden thunderstorms in the Midwest during summer.
Road Conditions
Check winter road reports if traveling between November and March.
Vehicle Check
Ensure your tires and fluids are checked before a long highway drive.
Emergency
Keep a roadside emergency kit in your trunk at all times.