To reach St. Louis from Edgartown, the most practical method is flying. Take the ferry to Woods Hole, travel to Boston Logan (BOS), and board a flight to St. Louis Lambert International Airport (STL). The total travel time is approximately 6 to 7 hours. This is the most efficient way to reach the Midwest from the island.
Total Distance: 1,800 km driving distance; 1,600 km straight-line air distance.
Most flights from Boston to St. Louis require a connection.
April to June or September to October for mild weather.