The drive from Everett to Buffalo is approximately 380 kilometers and takes about 4.5 hours. You will travel north on I-99 and then transition to I-79 North and I-90 East. This route takes you through the scenic hills of western Pennsylvania and into the lakefront city of Buffalo. It is a straightforward drive, though be prepared for lake-effect snow in the winter.
Total Distance: 380 km driving, 320 km air distance.
I-90 can be very windy near the lake.
Summer for Niagara Falls or Autumn for the foliage.