The trip from Fort Myers to Los Angeles covers roughly 2,300 miles. Flying is the only practical mode of transport, typically involving a connection in a hub like Dallas or Atlanta. The total travel time is usually between 7 and 10 hours including layovers. Driving is a massive undertaking, spanning over 40 hours of road time across the southern United States. Most travelers prefer the convenience of flying into LAX.
Total Distance: Driving distance 4,100 km, Air distance 3,700 km.
Check for flights with short layovers to minimize total travel time.
March to May or September to November for pleasant weather.