No direct train service between these two cities.

How long is the drive?

Approximately 5.5 hours of driving time.

No major tolls on this specific route.

Spring and fall offer the best weather.

Yes, it is a standard, well-traveled highway route.

Fort Scott

St. Louis

Driving

Fort Scott to St. Louis

Updated: 29 May 2026

The drive from Fort Scott to St. Louis is approximately 350 miles. You will travel north on US-69 and then transition to I-70. The journey takes about 5.5 hours of driving time. This is a direct and simple route across the Midwest.

Total Distance: Driving distance 560 km; Air distance 480 km.

Fastest Way

Driving via US-69 N and I-70 E is the fastest, taking 5.5 hours.

Cheapest Way

Driving is the most economical choice for this route.

Compare Fort Scott to St. Louis Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$60 - $80 (fuel)

Operator

Personal Vehicle

Route

US-69 N to I-70 E.

I-70 is a well-maintained highway with many stops.

Travel Tips

Traffic
Avoid St. Louis rush hour traffic if possible.
Parking
Use parking apps to find affordable garages in the city.
Navigation
Use GPS to navigate the highway systems in the city.
Dining
Try the local St. Louis-style pizza and toasted ravioli.
Events
Check local event calendars for concerts and festivals.

Safety Tips

Weather
Be prepared for sudden thunderstorms in the Midwest.
Fatigue
Take regular breaks to stay alert on the highway.
Road Conditions
Watch for construction zones on the highways.
Emergency
Keep a roadside emergency kit in your vehicle.