The trip from Frederick to Philadelphia is about 220 kilometers and takes 2.5 hours by car. You will travel east on I-70 and then north on I-95 toward Philadelphia. This is a popular route for those visiting the historic city. Public transit options are available, but driving is the most common method for this route.
Total Distance: 220 km driving, 190 km air distance.
I-95 can be very congested; use real-time traffic apps.
Anytime, but avoid rush hour for a smoother trip.