The drive from Gainesville to Little Rock spans approximately 650 miles. You will head west through Atlanta, Birmingham, and Memphis before taking I-40 W into Arkansas. This journey typically takes 10 to 11 hours of driving time. You will cross the Mississippi River at Memphis, which is a major landmark on this route. Expect heavy traffic in the Memphis metropolitan area during peak hours.
Total Distance: 1,045 km driving distance; 890 km straight-line air distance.
Take the I-22 shortcut from Birmingham to Memphis to save time.
Spring for the blooming dogwoods or autumn for the mild temperatures.