Is Memphis safe for tourists?

Yes, stick to tourist-friendly areas and practice standard safety precautions.

How long is the drive?

The drive takes about 6 to 6.5 hours.

No, this route is primarily toll-free.

What is the best time to visit?

Spring and fall are the most pleasant seasons.

Amtrak's City of New Orleans line stops in Memphis, but it is not a practical connection from Georgia.

Gainesville

Memphis

Driving

Gainesville to Memphis

Updated: 30 May 2026

The drive from Gainesville to Memphis covers approximately 400 miles. You will head south to Atlanta, then west on I-20 and I-22 through Birmingham. The journey takes about 6 to 6.5 hours of driving time. You will pass through the rolling hills of Alabama before reaching the Mississippi River. Expect heavy traffic in the Birmingham area during peak hours.

Total Distance: 645 km driving distance; 560 km straight-line air distance.

Fastest Way

Driving is the most practical method, as flights often require long layovers.

Cheapest Way

Driving is the most affordable way to reach Memphis from Gainesville.

Compare Gainesville to Memphis Routes

Driving

Direct

Duration

6 hours 15 mins

Avg Price

$60-$90 in fuel

Operator

Personal Vehicle

Route

I-985 S to I-285 W to I-20 W to I-22 W.

Stop in Birmingham for a quick lunch at a local BBQ joint.

Travel Tips

Traffic
Avoid the Birmingham interchange during the 5 PM rush hour.
Rest Stops
Use the rest areas along I-22 for safe breaks.
Navigation
Use a GPS to navigate the city streets of Memphis.
Dining
Try the famous Memphis-style dry rub ribs at a local BBQ restaurant.
Booking
Book your hotel in advance if visiting during a major festival.

Safety Tips

City Safety
Stick to well-lit, populated areas when exploring downtown at night.
Weather
Check for severe weather alerts in the Mississippi Delta region.
Vehicle Check
Ensure your tires are properly inflated before starting this trip.
Emergency Kit
Keep a basic first-aid kit and water in your car.