Is there a direct train to St. Louis?

No, you must transfer in Chicago when traveling from Glenwood Springs.

How long is the drive to St. Louis?

The drive takes approximately 17 to 19 hours depending on traffic and stops.

What is the best highway to take?

Interstate 70 is the primary and most direct route connecting Colorado to Missouri.

Are there tolls on this route?

Yes, expect some tolls in Kansas and near the St. Louis metropolitan area.

Can I fly from Glenwood Springs?

No, you must drive to Denver International Airport to catch a flight to St. Louis.

Glenwood Springs

St. Louis

Train Driving

Glenwood Springs to St. Louis

Updated: 28 May 2026

The journey from Glenwood Springs to St. Louis spans approximately 1,150 miles across the American heartland. You can take the Amtrak California Zephyr from the Glenwood Springs Station directly to Chicago, then transfer to a regional train or drive via I-70 East. Driving takes roughly 17 hours of pure transit time through Kansas and Missouri. The route offers a dramatic transition from the Rocky Mountains to the rolling plains of the Midwest. Expect varied weather conditions, especially when crossing the Continental Divide.

Total Distance: 1,850 km driving distance; 1,580 km straight-line air distance.

Fastest Way

Driving is faster than rail, taking 17 hours compared to over 30 hours by train.

Cheapest Way

Driving is generally cheaper for groups of two or more people.

Compare Glenwood Springs to St. Louis Routes

	Train Connecting	Driving Direct
Duration	32 hours	17 hours
Avg Price	$250 - $450	$200 - $300 in fuel
Operator	Amtrak California Zephyr	Personal Vehicle
Route	Glenwood Springs to Chicago Union Station, then transfer to Lincoln Service.	I-70 East through Denver, Hays, Kansas City, and Columbia.
Tip	Book a roomette for overnight comfort on the long stretch through Nebraska.	Watch for heavy truck traffic near Kansas City and construction zones on I-70.

Travel Tips

Pack Layers
Temperatures fluctuate significantly between the high-altitude Rockies and the humid Missouri valley.
Check I-70 Closures
Always verify road conditions in the mountains before departing, as winter storms can close passes.
Book Amtrak Early
Prices for the California Zephyr increase significantly as the departure date approaches.
Stay Hydrated
The dry air in Colorado can cause dehydration before you even start your long drive.
Use Rest Stops
Plan your stops in Kansas carefully, as stretches between major towns can be long and desolate.

Safety Tips

Mountain Driving
Use lower gears when descending steep grades on I-70 to prevent brake overheating.
Wildlife Awareness
Be vigilant for deer and elk on the roads, especially during dawn and dusk hours.
Emergency Kit
Carry a winter emergency kit including blankets, water, and snacks in your vehicle.
Tire Pressure
Check your tire pressure before leaving, as altitude changes affect inflation levels.