The journey from Grand Rapids to St. Louis is a 1,050-kilometer drive south through Minnesota, Iowa, and into Missouri. You will follow I-35 to Des Moines and then head east on I-80 and I-70. The drive takes about 11 hours. St. Louis is famous for the Gateway Arch, its historic neighborhoods, and vibrant cultural scene.
Total Distance: 1,050 km driving, 850 km air distance.
This is a long drive; plan for an overnight stop if necessary.
Spring and fall for mild weather and outdoor activities.