The drive from Greenville to Chattanooga covers approximately 500 miles. The most direct route is via I-40 West to I-75 South. Expect a travel time of roughly 8 hours. This route takes you through the beautiful mountains of North Carolina and Tennessee. Plan for a stop in Asheville to enjoy the scenery.
Total Distance: Driving distance 800 km, air distance 650 km.
Be prepared for heavy traffic near Knoxville.
May or October for comfortable temperatures and outdoor activities.