Driving
Greenwood to Des Moines
Updated: 28 May 2026
The drive from Greenwood to Des Moines is a 900-mile journey across the heart of the US. You will primarily use I-55 N and I-35 N, passing through the Midwest. The trip takes about 14 hours of driving time. Des Moines is famous for its vibrant downtown and the Iowa State Capitol. Prepare for a long, scenic drive through the plains.
Total Distance: 1448 km driving, 1200 km air distance.
Fastest Way
Driving is the most practical method for this route.
Cheapest Way
Driving is the most economical way to reach Des Moines.
Compare Greenwood to Des Moines Routes
Driving
Direct
Duration
14 hours
Avg Price
$160-$240 in fuel
Operator
Personal Vehicle
Route
I-55 N, I-35 N.
Plan for an overnight stop in St. Louis.
Travel Tips
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Overnight StopsBook hotels in advance in cities like St. Louis.
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HydrationCarry plenty of water for the long stretches.
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NavigationUse GPS to navigate the plains.
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DiningTry the local food in Des Moines.
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WeatherBe prepared for snow in the winter.
Safety Tips
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FatigueDo not attempt this drive in one sitting.
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Vehicle PrepCheck your tires and brakes before the trip.
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Emergency KitCarry extra water and food.
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Road ConditionsCheck for snow in the winter.
People Also Ask
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Is it a long drive?Yes, it is over 900 miles.
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Are there tolls?Some sections of the route may have tolls.
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What is the best route?I-55 N to I-35 N is the most direct path.
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Is Des Moines safe?It is generally safe, but standard urban precautions apply.
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Can I fly?Yes, but flights are expensive and require connections.
Quick Info
- From Greenwood, Mississippi, United States
- To Des Moines, Iowa, United States
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Modes
Best Time to Travel
Summer for the best weather.
Things to Do in Des Moines
1
Iowa State Capitol
Tour the beautiful capitol building with its gold-leaf dome.
2
Greater Des Moines Botanical Garden
Explore the beautiful gardens and conservatory.
3
Des Moines Art Center
Discover a wide range of art in this beautiful museum.
4
East Village
Explore the shops and restaurants in this vibrant district.
Tags
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