Driving
Greenwood to St. Louis
Updated: 28 May 2026
The drive from Greenwood to St. Louis covers 400 miles and takes about 6 hours via I-55 North. You will travel through the heart of Mississippi, Tennessee, and into Missouri. This route is a major corridor connecting the Delta to the gateway city of St. Louis. A personal vehicle is the most practical mode of transport for this trip.
Total Distance: 640 km driving distance; 550 km straight-line air distance.
Fastest Way
Driving via I-55 is the fastest route at 6 hours.
Cheapest Way
Driving your own car is the most economical option.
Compare Greenwood to St. Louis Routes
Driving
Direct
Duration
6 hours
Avg Price
$70-$95 in fuel
Operator
Personal Vehicle
Route
I-55 N
I-55 is a major interstate with frequent service stations.
Travel Tips
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TrafficExpect heavy traffic entering St. Louis on I-55.
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DiningTry the local barbecue and toasted ravioli.
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NavigationUse GPS to navigate the city's interstate loop.
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ParkingDowntown St. Louis has many paid parking garages.
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SafetyStay in well-populated areas, especially at night.
Safety Tips
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Speed LimitsWatch for speed limit changes on I-55.
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WeatherBe aware of potential severe weather in the region.
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FatigueTake a break in Memphis to stretch.
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EmergencyKeep a roadside assistance number handy.
People Also Ask
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Is there a train to St. Louis?Yes, Amtrak's Texas Eagle line stops in St. Louis.
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How long is the drive?The drive takes about 6 hours.
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What is the best route?Taking I-55 North is the standard route.
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Is St. Louis safe?Exercise standard urban safety precautions.
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Are there tolls?No, this route is toll-free.
Quick Info
- From Greenwood, Mississippi, United States
- To St. Louis, Missouri, United States
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Modes
Best Time to Travel
October for the pleasant weather and outdoor festivals.
Things to Do in St. Louis
1
Gateway Arch
Visit the iconic monument.
2
St. Louis Zoo
Explore the world-renowned zoo.
3
Forest Park
Enjoy hiking and outdoor activities.
4
City Museum
Visit the interactive museum.
Tags
Greenwood to St. Louis drive
I-55 route
driving to St. Louis
Mississippi to Missouri travel
St. Louis road trip
Greenwood MS to St. Louis
fastest way to St. Louis
St. Louis travel guide
