The journey from Hamburg, New York to Chicago, Illinois is approximately 500 miles. You can drive via I-90 West, which is a direct route through Pennsylvania, Ohio, and Indiana. Alternatively, you can take the Amtrak Lake Shore Limited from the Buffalo-Depew station. Chicago is a world-class city known for its architecture, museums, and deep-dish pizza. This route is a major corridor connecting the Northeast to the Midwest.
Total Distance: 800 km driving distance; 650 km straight-line air distance.
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Direct
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Direct
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| Duration | 10 hours | 8 hours |
| Avg Price | $90 - $200 | $80 - $120 in fuel |
| Operator | Amtrak Lake Shore Limited | Personal Vehicle |
| Route | Buffalo-Depew to Chicago Union Station. | I-90 West all the way to Chicago. |
| Tip | The train is comfortable and offers a relaxing way to travel across the Midwest. | I-90 has several toll sections in Indiana and Illinois; use an E-ZPass. |
May to September for pleasant weather and lakefront activities.