The journey from Harrison to Evansville spans approximately 650 kilometers. You will primarily utilize US-65 North to reach the interstate system. Transitioning to I-64 East provides the most direct path through Missouri and Illinois. Expect a travel time of roughly 7 hours depending on traffic near St. Louis. This route crosses the Mississippi River, offering scenic views of the Midwest landscape.
Total Distance: 650 km driving distance, 580 km straight-line air distance.
Avoid rush hour traffic in St. Louis to save significant time.
September to October for mild weather and fall foliage along the Ozark foothills.