The drive from Horse Cave to Baltimore is approximately 600 miles. You will head east on I-64 and then transition to I-70, which takes you through the mountains and into Maryland. The drive typically takes 10 hours. This route is a major east-west corridor through the Appalachian Mountains. Expect heavy traffic near Baltimore during peak hours.
Total Distance: 965 km driving distance; 810 km straight-line air distance.
Stop in Hagerstown, Maryland, for a quick break.
Spring and Autumn are the best times to visit Baltimore for comfortable weather.