The drive from Horse Cave to Birmingham is a direct route south on I-65. You will pass through Nashville, Tennessee, before crossing into Alabama. The total distance is approximately 290 miles, taking about 4.5 hours of driving time. This route is a major north-south corridor through the heart of the South. Expect heavy traffic near Nashville and Birmingham during peak hours.
Total Distance: 467 km driving distance; 410 km straight-line air distance.
Stop in Cullman, Alabama, for a quick break.
Spring and Autumn are the best times to visit Birmingham for comfortable weather.