The journey from Horse Cave to Charleston is a trip of approximately 650 miles. You will head south to I-75 South, which takes you through Tennessee and into South Carolina, before connecting to I-26 East into Charleston. This route takes you through the heart of the South. Expect a total drive time of 10 hours or more. It is a straightforward drive through scenic landscapes.
Total Distance: 1,050 km driving distance; 850 km straight-line air distance.
Plan for a stop in Asheville to break up the drive.
Spring or autumn to avoid the humid summer heat in South Carolina.