Driving
Huntington to St. Louis
Updated: 28 May 2026
The drive from Huntington to St. Louis is approximately 350 miles and takes about 5 hours and 30 minutes. You will head south to Indianapolis and then take I-70 West all the way to St. Louis. This route takes you through the heart of Indiana and Illinois. St. Louis is a historic city on the Mississippi River, famous for the Gateway Arch. There is no direct public transit between these two cities.
Total Distance: 560 km driving distance; 480 km straight-line air distance.
Fastest Way
Driving via I-69 and I-70 is the fastest route, typically taking 5 hours and 30 minutes.
Cheapest Way
Driving your own vehicle is the most cost-effective way to reach St. Louis.
Compare Huntington to St. Louis Routes
Driving
Direct
Duration
5 hours 30 mins
Avg Price
$70-$80 in fuel
Operator
Personal Vehicle
Route
I-69 South to I-70 West
Traffic can be heavy entering St. Louis; plan your arrival accordingly.
Travel Tips
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ParkingUse the parking garages downtown for easy access to attractions.
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DiningExplore the restaurants in the Soulard neighborhood.
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NavigationSt. Louis's highway system can be complex; keep your GPS active.
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EventsCheck the schedule for events at the Enterprise Center.
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WalkingThe riverfront area is great for a walk with views of the Mississippi River.
Safety Tips
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TrafficBe aware of heavy traffic on I-70 during rush hour.
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PedestriansWatch for pedestrians in the downtown area.
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EmergencyKeep your phone charged for navigation and emergency calls.
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Road SafetyAvoid driving during heavy rain, as some roads can become slick.
People Also Ask
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Is there a bus to St. Louis?No, there is no direct public bus service from Huntington.
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How long is the drive?It takes about 5 hours and 30 minutes.
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What is the best route?Taking I-69 South to I-70 West is the standard route.
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Are there tolls?No, this route is toll-free.
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Is it a safe drive?Yes, it is a standard highway drive.
Quick Info
- From Huntington, Indiana, United States
- To St. Louis, Missouri, United States
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Modes
Best Time to Travel
Spring or autumn for pleasant weather to explore the city's parks.
Things to Do in St. Louis
1
Gateway Arch National Park
The iconic monument to westward expansion, offering tram rides to the top.
2
St. Louis Zoo
A world-class zoo with free admission and diverse animal exhibits.
3
City Museum
A unique, interactive playground built from repurposed industrial materials.
4
Forest Park
A massive urban park featuring museums, a zoo, and beautiful green spaces.
Tags
Huntington to St. Louis
drive to St. Louis
Indiana to Missouri
I-70 route
St. Louis travel guide
Huntington IN road trip
St. Louis weekend
driving directions
