Yes, Amtrak runs the Lake Shore Limited from Cleveland.

What is the best way to travel?

Driving is flexible, but the train is relaxing.

Yes, the route involves several toll roads.

Tourist areas are generally safe, but stay aware.

Independence

Chicago

Train Driving

Independence to Chicago

Updated: 28 May 2026

The drive from Independence to Chicago is approximately 340 miles, taking about 5.5 hours via I-80/I-90 West. You will pass through Indiana and into Illinois. Chicago is a major metropolitan hub known for its architecture, deep-dish pizza, and lakefront parks. Be prepared for heavy traffic near the city and significant tolls.

Total Distance: Driving distance 550 km, straight-line air distance 480 km.

Fastest Way

Driving via I-80/I-90, taking 5.5 hours.

Cheapest Way

Driving is generally cheaper for groups, while Amtrak is competitive for solo travelers.

Compare Independence to Chicago Routes

	Train Direct	Driving Direct
Duration	6 hours	5 hours 30 mins
Avg Price	$60 - $150	$60 in fuel + $30 tolls
Operator	Amtrak	Personal Vehicle
Route	Cleveland Station to Chicago Union Station	I-80 W to I-90 W
Tip	The Lake Shore Limited train is a comfortable way to travel.	Use an E-ZPass to navigate the multiple toll roads efficiently.

Travel Tips

Tolls
Ensure you have an E-ZPass for the Indiana and Illinois toll roads.
Traffic
Avoid entering Chicago during morning or evening rush hours.
Parking
Parking in downtown Chicago is very expensive; use public transit or parking apps.
Transit
The 'L' train system is the best way to get around the city.
Dining
Try deep-dish pizza at a local favorite like Lou Malnati's.