The drive from Isle of Palms to Orlando is a 650-kilometer journey south. You will follow I-95 South and then I-4 West, taking approximately 6.5 to 7 hours. Orlando is famous for its theme parks and attractions. The route takes you through the Carolinas, Georgia, and into Florida. It is a popular route for families traveling to the theme parks.
Total Distance: 650 km driving distance; 580 km straight-line air distance.
Expect heavy traffic on I-4 near Orlando.
Spring and fall for pleasant weather and fewer crowds.