Is US-395 a safe road?

Yes, it is a well-maintained highway, though it is remote in sections.

How long is the drive?

The drive takes about 11 hours without major stops.

Are there mountain passes?

Yes, you will cross several high-elevation passes in the Cascades and Sierra Nevada.

Yes, but flights from Seattle usually require a connection in San Francisco or Salt Lake City.

What is the best time to drive?

Daylight hours are best to enjoy the scenery and avoid wildlife.

Issaquah

Reno

Driving

Issaquah to Reno

Updated: 28 May 2026

The route from Issaquah to Reno is a stunning 950-kilometer journey that takes you through the heart of the Cascade Mountains and the high desert. You will head east on I-90 before transitioning to the scenic US-395 South. This route is favored by road-trippers for its dramatic mountain vistas and access to Eastern Oregon and Northern Nevada. Expect a drive time of approximately 11 hours depending on weather and stops.

Total Distance: 950 km driving distance; 780 km air distance.

Fastest Way

Driving is the primary practical mode; flights require connections and are often more expensive.

Cheapest Way

Driving your own vehicle is the most economical way to reach Reno from Issaquah.

Compare Issaquah to Reno Routes

Driving

Direct

Duration

11 hours

Avg Price

$160-$220 in fuel

Operator

Personal Vehicle

Route

I-90 East to US-395 South.

The stretch of US-395 through the high desert is remote; ensure your gas tank is full.

Travel Tips

Mountain Weather
Always carry tire chains if traveling between November and April, as passes can close suddenly.
High Desert Sun
The sun is intense at high altitudes; wear sunscreen even during cooler months.
Cell Service
Expect long stretches of no cell service on US-395; download offline maps before leaving.
Hydration
The air is very dry in Nevada; drink plenty of water to avoid altitude sickness.
Fuel Planning
Plan your fuel stops in larger towns like Bend or Susanville to avoid running low in remote areas.

Safety Tips

Wildlife Awareness
Be cautious of deer and elk crossing the road, especially during dawn and dusk.
Speed Limits
Observe posted speed limits strictly, as Nevada highway patrol is active on US-395.
Vehicle Prep
Check your cooling system, as the high desert heat can stress older engines.
Emergency Supplies
Keep a blanket and extra food in your car, as temperatures drop significantly at night.